مقایسه‌ تأثیر یک برنامه تمرین درمانی و مصرف خوراکی زعفران بر مقادیر IL-6، TNF-a و کنترل گلایسمیک در زنان چاق دیابتی نوع 2

Background: The purpose of this study was comparison of the effect of a therapeutic exercise program and oral administration of saffron on the levels of IL-6, TNF-a and glycemic control in type 2 diabetic women Methods: 48 type 2 diabetic obese women were randomly divided into four equal groups (saffron + training, training + placebo, saffron, placebo). The saffron group + training and training + placebo groups performed aerobic training with intensity of 60-75% of maximal heart rate for 8 weeks (three sessions per week). Daily dose of 400 mg of Saffron sprout powder (once a day) was used for two months. The placebo contained 400 mg of wheat flour. The following IL-6, TNF-a, Blood glucose and HbA1c variables; lipid profiles and HOMA-IR were tested. The Shapiro-Wilk test, variance analysis with repeated measures, Bonferron's post hoc test, and one way analysis of variance with LSD post-test. Results: In the post-test phase, the pre-test the variables IL-6 and TNF-&alpha;, blood glucose and HbA1c in intervention groups decreased significantly, and also in the post-test between group, saffron + training with training + placebo, saffron + training&nbsp; with saffron, saffron + training&nbsp; with placebo and saffron with placebo there was a significant difference (p<0.05). Also, in variables of weight and BMI, there were statistically significant differences between saffron + training with placebo groups, training + placebo with placebo groups, and saffron with the placebo groups (p<0.05). Conclusion: It can be possible aerobic exercise and saffron consumption have a protective effect against the increased levels of blood glucose and HbA1c. It is possible that the reduction of blood glucose, IL-6 and TNF-a in saffron recipients is due to the presence of saffron metabolites, especially flavonoids (crostein and crocin) and increased antioxidant defense system through saffron.